Anti N-methyl-D-aspartate receptor encephalitis: A case series from Myanmar

Authors

  • Aye Myat Nyein Department of Neurology, North Okkalapa General and Teaching Hospital, Yangon, Myanmar
  • Khaing Zar Win Department of Neurology, University of Medicine 2, Yangon, Myanmar
  • Min Theing Naing Department of Neurology, University of Medicine 2, Yangon, Myanmar
  • Swe Kyinn Department of Neurology, University of Medicine 2, Yangon, Myanmar
  • Aye Aye Sann Department of Neurology, University of Medicine 2, Yangon, Myanmar

DOI:

https://doi.org/10.54029/2022swp

Keywords:

anti-NMDAR-encephalitis, teratoma, delta brush, myanmar, psychotic, hyperkinetic, plasma exchange

Abstract

Objectives: Since 2007, anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis has been increasingly reported worldwide. Although the diagnostic testing of anti-NMDAR encephalitis was available in Myanmar since 2016, there have been no studies reported so far. This is a report of anti- NMDAR encephalitis admitted to one of the tertiary care hospitals in Myanmar.

Methods: It is an observational study of anti-NMDAR encephalitis admitted at North Okkalapa General and Teaching Hospital (NOGTH) for three consecutive years.

Results: In this study, ten patients diagnosed as anti- NMDAR encephalitis were included. Median age of onset was 21 years, ranged from 16 to 85 years. Nine out of ten patients were female (90%). Seven patients (70%) showed four of the six major groups of symptoms. Only one patient (10%) was found to have ovarian teratoma. EEG abnormalities were observed in all patients (100%). Out of six MRIs done, four (66.6%) were normal.

Conclusion: This study showed that demographic profile, clinical characteristics, and ancillary test results were in similarity with other previous studies but mortality rate of 40% was relatively high as compared to previous studies.

Published

2022-03-31

Issue

Vol. 27 No. 1 (2022)

Section

Original Article