Clinical characteristics of ischemic stroke in patients with positive ANCA

Authors

  • Xiaoyan Li Department of Clinical Laboratory, Baoding NO.1 Central Hospital, Baoding, Hebei, China
  • Jingjing Cui Department of Clinical Laboratory, Baoding NO.1 Central Hospital, Baoding, Hebei, China
  • Xin Liu Department of Clinical Laboratory, Baoding NO.1 Central Hospital, Baoding, Hebei, China
  • Yue Hu Department of Clinical Laboratory, Baoding NO.1 Central Hospital, Baoding, Hebei, China
  • Yao Wei Department of Clinical Laboratory, Baoding NO.1 Central Hospital, Baoding, Hebei, China
  • Xiangyu Li Department of Clinical Laboratory, Baoding NO.1 Central Hospital, Baoding, Hebei, China
  • Zhichao Zu Department of Clinical Laboratory, Baoding NO.1 Central Hospital, Baoding, Hebei, China
  • Xing Yao Department of Clinical Laboratory, Baoding NO.1 Central Hospital, Baoding, Hebei, China
  • Yaping Guo Department of Clinical Laboratory, Baoding NO.1 Central Hospital, Baoding, Hebei, China.

DOI:

https://doi.org/10.54029/2022zjv

Keywords:

ANCA, recurrence of ischemic stroke, respiratory tract infection, pulmonary interstitial lesions

Abstract

Objective: To explore the clinical characteristics and recurrence rate of ischemic stroke in patients with antineutrophil cytoplasmic antibody (ANCA) , to improve the early diagnosis of these patients, so as to take effective measures to control the progress of the disease and reduce the mortality.

Methods: A retrospective analysis of the ischemic stroke patients with ANCA positive and negative status from the neurology department, Baoding No. 1 Central Hospital, Hebei, China.

Results: The prevalence of ANCA in 1,297 ischemic stroke patient was 10.10%. The rate of recurrence of ischemic stroke in ANCA positive group was significantly higher than that in ANCA negative group (70.99% vs 35.08%, p < 0.05). The proportion of small-artery occlusion in ANCA positive group was also significantly higher than that in ANCA negative group (33.59% vs 21.96%, p=0.003). The proportion of respiratory tract infection in ANCA positive group (54.96%) was higher than that in ANCA negative group (p < 0.05). The proportion of pulmonary interstitial lesions detected by chest CT in the ANCA positive group was also significantly higher (33.59%) than the ANCA negative group (P < 0.05).

Conclusion: ANCA positive etiology accounts for about 10% of ischemic stroke. There is higher rate of recurrent stroke and small artery occlusion.

Published

2022-03-31

Issue

Vol. 27 No. 1 (2022)

Section

Original Article