Keywords:
Drug-induced parkinsonism, Amiodarone
Abstract
Drug-induced parkinsonism (DIP) is the second most common cause of parkinsonism, primarily resulting from medications that block dopamine D2 receptors or reduce dopamine in the basal ganglia. While antipsychotics are most frequently linked to DIP, cases related to other agents like amiodarone are rare. We describe a 79-year-old Filipino woman with sick sinus syndrome who developed parkinsonian symptoms after two months of amiodarone therapy. A high Nanjaro score, lack of response to levodopa, and dramatic improvement following discontinuation of amiodarone all aided the diagnosis of DIP. Supporting features include acute-subacute onset, timing of symptom development and absence of non-motor signs typical of PD. In conclusion, although rare, amiodarone can be associated with parkinsonism, highlighting the importance of clinical suspicion and vigilance, as the motor features of DIP can closely mimic those of PD.
Author Biographies
Cid Czarina Diesta, Makati Medical Center
Dr. Cid Czarina Diesta is a Neurology consultant at the Makati Medical Center and Asian Hospital and Medical Center with subspecialty in Movement Disorder and heads the Movement Disorder Center of the Makati Medical Center and the Asian Hospital and Medical Center. She teaches on special topics at the following medical schools: San Beda College of Medicine, Ateneo College of Medicine and Lyceum College of Medicine. She has lectureships on different topics of Neurology and Movement Disorders. Dr. Diesta has been active in the Movement Disorder Society of the Philippines. She previously served as vice president and currently a member of the organization. Her research interests are on different movement Disorders such as X linked dystonia parkinsonism (XDP), Parkinson’s disease, Spinocerebellar ataxia, Hemifacial spasms and DRPLA. She has ongoing collaborative researches with University of Lubeck in Germany and Massachusetts General Hospital, in Boston on X-linked dystonia Parkinsonism. Her interests has led to recent significant publications on X-linked Dystonia Parkinsonism as follows: Basal Ganglia Atrophy as a Marker for Prodromal X-linked Dystonia-Parkinsonism, Elucidating Hexanucleotide Repeat Number and Methylation within the X-Linked Dystonia-Parkinsonism (XDP)-Related SVA Retrotransposon in TAF1 with Nanopore Sequencing.
Jed Noel Ong, Makati Medical Center
Dr. Jed Noel Ong is an Adult Neurologist at the Makati Medical Center and Chinese General Hospital and Medical Center with the subspecialty in Parkinson’s Disease and Movement Disorders. He is currently the Training Officer of the Movement Disorders Fellowship of Makati Medical Center. Dr. Ong has been active in the field of Movement Disorders in the Philippines as he is the current Treasurer of the Movement Disorder Society of the Philippines, a member of the Movement Disorders Council of the Philippine Neurological Association and the head of the Movement Disorders Database of the Philippine Neurological Association. He is also the current representative of the Philippines for Asian Oceanian Association of Neurology Young Members Group and is part of the organizing committee of the upcoming lecture series in Movement Disorders. He is likewise an active member of the International Parkinson’s Disease and Movement Disorders Society and is part of the MDS Movement Disorders in Asia Study Group. He is also part of the faculty of San Beda University College of Medicine and teaches Neuroscience and Neuroanatomy. His research interests are on different movement disorders particularly on Parkinson’s Disease, Atypical Parkinsonism and X-Linked Dystonia Parkinsonism. He is part of the ongoing collaborative studies on X-Linked Dystonia Parkinsonism between with Makati Medical Center and University of Lübeck in Germany.
