Authors
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Ming Zou
Department of Geriatric Neurology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250021, China.
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Jian-Yong Wang
Department of Geriatrics & Neurology, the Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China
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Ren-Jun Lv
Department of Geriatric Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China.
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Shan-Jing Nie
Department of Geriatric Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China.
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Lan-Bing Zhu
Department of Geriatrics & Neurology, the Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China
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Xue-Ping Liu
Shandong University
Keywords:
Parkinson’s disease, Polymorphism, Autophagy-related gene 7, Autophagy, Association
Abstract
Background & Objective: Deregulation of autophagy is involved in the development and progression of Parkinson’s disease. ATG7, an E1 like enzyme, plays a key role in autophagy. This study aimed to investigating the association between ATG7 polymorphisms and PD susceptibility.
Methods: Single nucleotide polymorphisms of ATG7, including rs7625184 and rs2606750, were identified by polymerase chain reaction-restriction fragment length polymorphism in a Han Chinese population consisting of 312 PD patients and 309 healthy controls.
Results: Genotyping analyses showed that none of the 2 SNPs was significantly associated with PD risk.
Conclusions: Our results suggest that rs7625184 and rs2606750 are not associated with PD susceptibility. Further studies are warranted to reveal the links between ATG7 and PD.
Author Biographies
Ming Zou, Department of Geriatric Neurology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250021, China.
Jian-Yong Wang, Department of Geriatrics & Neurology, the Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China
Ren-Jun Lv, Department of Geriatric Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China.
Shan-Jing Nie, Department of Geriatric Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China.
Lan-Bing Zhu, Department of Geriatrics & Neurology, the Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China
