Reversible cerebral vasoconstriction syndrome associated with paroxysmal nocturnal hemoglobinuria: A case study

Authors

  • Qianqian Fan The Affiliated Haikou Hospital of Xiangya Medical College, Central South University
  • Yongmin Chen The First Affiliated Hospital of Hainan Medical University
  • Dandan Jia The First Affiliated Hospital of Hainan Medical University
  • Zhenhua Song The Affiliated Haikou Hospital of Xiangya Medical College, Central South University
  • Qifu Li The First Affiliated Hospital of Hainan Medical University

DOI:

https://doi.org/10.54029/2025mev

Keywords:

paroxysmal nocturnal hemoglobinuria, reversible cerebral vasoconstriction syndrome, reversible vasospasm, seizures, thunderclap headaches

Abstract

Reversible cerebral vasoconstriction syndrome (RCVS), characterized by thunderclap headaches (TCH) and other clinical and radiological manifestations, typically occurs under some triggering conditions. This is the report of a 43 years old woman with known paroxysmal nocturnal hemoglobinuria (PNH) who received regular blood transfusion and glucocorticoid treatment, and developed RCVS. The association between PNH and RCVS has not been previously reported.

Published

2025-12-28

Issue

Vol. 30 No. 4 (2025)

Section

Case Report