Rare trigeminovascular signs during migraine attack

Abstract

Severe headache and physical findings in the face and neck area may imply serious intracranial pathology and warrant further investigations including laboratory tests and imaging. We present two migraine cases with unusual trigeminovascular cutaneous findings (i.e., periorbital bruising and facial swelling). Recognition of these rare manifestations of migraine may help the clinician in differential diagnosis and prevent unnecessary investigations. A pathophysiological discussion of these signs is provided.