Neuropsychiatric lupus with cerebral cortical lamellar necrosis: A case report

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease, and when it presents with neurological complications, it is termed neuropsychiatric systemic lupus erythematosus (NPSLE). Cortical laminar necrosis (CLN) refers to the necrosis of neurons in one or more layers of the cerebral cortex. This report presents a case of NPSLE with CLN in a 43-year-old female patient, diagnosis was based on clinical manifestations and MRI. The pathogenesis of CLN is complex, and its clinical presentations are varied. Thus, future research should focus on enhancing the understanding of this disease to improve its diagnosis and treatment.