Analysis of clinical features and literature review of myelin oligodendrocyte glycoprotein antibody-associated disease

Abstract

Objective: The purpose of this study is to analyze the clinical features of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD).

Methods: A retrospective analysis was conducted on eight patients diagnosed with MOGAD at Anyang City People’s Hospital, Henan, China.

Results: Among the eight patients, five were male and three were female, with an age range of 31 to 68 years and a median age of 46.88 years. Both serum and/or cerebrospinal fluid were tested positive for the MOG antibody. Optic neuritis, myelitis, and cortical encephalitis were among the clinical manifestations. A history of viral infection prior to the onset of the disease (3/8) was observed, and one case also tested positive for the AQP-4 antibody.

Conclusion: Optic neuritis and myelitis are the primary clinical manifestations of MOGAD, while a small percentage of patients also exhibit cerebral encephalitis. Testing for the MOG antibody holds diagnostic significance as the condition is easily misdiagnosed.