Use of CALLY index to predict aneurysmal subarachnoid hemorrhage patient outcome

Abstract

Background & Objective: Aneurysmal subarachnoid hemorrhage (aSAH) is a condition linked to elevated mortality and morbidity rates. Despite limited knowledge of the exact mechanism in aSAH patients, systemic inflammation is thought to have a significant role in cerebrovascular disease. The CALLY index is a prognostic marker utilized in many diseases, derived from parameters such as CRP, albumin, and lymphocytes. Nevertheless, there is limited research on its implementation in aSAH patients. This study aimed to investigate the CALLY index’s prognostic usefulness in aSAH patients.

Methods: The research cohort comprises patients who attended a tertiary teaching and research hospital’s emergency department between January 1st, 2021, and January 1st, 2022, with a confirmed diagnosis of aneurysmal rupture. Basic demographic data and associated comorbidities of the cohort, in addition to the CALLY index derived from CRP, albumin, and lymphocyte levels, were documented. A comparison of the effects of investigations and data on in-patient mortality between the groups was conducted.

Results: A total of 190 patients who met the inclusion criteria participated in the study. Patients with mortality were observed to have significantly lower CALLY Index scores than those in the other group (1.940 vs. 8.805). Regression analysis showed that mortality could be predicted based on the CALLY index (OR 0.393, 95% CI 0.1511-1.058, p=0.058). An AUC of 0.752, sensitivity of 78.2, specificity of 59.8 [p<0.001] was achieved by the optimal value for CALLY index.

Conclusion: Based on the findings of this study, it can be inferred that CALLY index is a simple marker which can serve as an indicator of mortality in aSAH patients.