Paraneoplastic seropositive AQP4-IgG neuromyelitis optica spectrum disorder associated with sigmoid adenocarcinoma

Abstract

Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing demyelinating and inflammatory disease of the central nervous system, mediated by aquaporin-4 (AQP4)-immunoglobulin G (IgG) autoimmunity. Although NMOSD is most commonly an idiopathic autoimmune condition, it may also occur as a paraneoplastic syndrome in rare instances. Hereby, we report a rare case of a 61-year-old lady with paraneoplastic AQP4-IgG NMOSD associated with adenocarcinoma of sigmoid colon.